Program Satellite Meetings

Introduction to Adverse Outcome Pathways and the AOP Wiki*

Sunday, August 20, 2017, 10:00 AM  - 12:00 PM
Sheraton Seattle, Aspen Room

*Seperate registration

This training will provide information on the AOP concept and development programs, present principles and advice for AOP development and use via demonstrative case studies, and allow time for hands-on practice entering information into the AOP Wiki. Additional resources and training modules will also be highlighted.

Version 2.0 of the AOP Wiki was released in November 2016, and this seminar will be ideal for those wishing to gain some hands-on experience with the new version as well as those who are new to the AOP concept.

Schedule:

10:00:     Introduction to the OECD AOP Programme and Online Training course
Kate Willett, Human Toxicology Project Council

10:40:     Building AOPs for Neurotoxicity: Perspective from an Academic
Prof. Dr. Ellen Fritsche, IUF – Leibniz Research Institute for Environmental Medicine

11:20:     Demonstration and Hands-On Activity with AOP Wiki
Kristie Sullivan, Physicians Committee for Responsibility Medicine

Sponsors: Human Toxicology Project Consortium and the Physicians Committee for Responsible Medicine

For more information please contact ksullivan@pcrm.org.



Workshop on Severity Classification and Reporting - Foucs on continuous Refinement

Sunday August 20, 2017, 14:00-16:00
Washington State Convention Center Rooms 613-614

Facilitators:
David Anderson & Katrin Schu╠łtte

Directive 2010/63/EU introduced the requirement for the classification of procedures (Article 15) during the application for project authorisation to use animals in scientific procedures in Europe. It also introduced the requirement to report the actual severity experienced by each animal used in a procedure. Consistency of assignment of severity categories is a key requirement to promote harmonization in animal use and statistical reporting.

Most importantly, both these processes provide an excellent opportunity for a continued focus on refinement and minimization of adverse effects of procedures.

The training workshop will consist on an introduction to the severity framework followed by interactive sessions on approaches to prospective severity classification and actual severity assessment.

Discussion session will review the approaches to ensure application of the most refined procedures and consistent and accurate determination of reporting of the severity of procedure experienced by each individual animal used.


In addition to improving the welfare of animals, the opportunities throughout the project to consider the design and conduct of the studies can reasonably be expected to improve scientific quality and outcomes.

Contributions from attendees working under different legislation will be encouraged to compare and contrast the approaches to assessment and reporting of severity.

Maximum: 50 contributors

Register:



NA 3Rs Collaborative Business Meeting

Sunday August 20, 2017, 07:00 – 17:00
The Sheraton Seattle, Issaquah Room
 


Physicians Committee for Responsible Medicine (PCRM) How Can We Break Through the Scientific and Cultural Barriers to Nonanimal Research? A Workshop and Brainstorm


Sunday August 20, 2017, 15:30 – 18:00
The Sheraton Seattle, Ballard Room, 3rd Floor

Researchers, students, and others working to advance animal replacement initiatives are invited to join us at this workshop to review emerging trends in non-animal research and to brainstorm regarding the current barriers and necessary resources to rapidly advance human-based research and discovery.

The meeting will feature several short, stimulating talks from thought leaders. Then participants will break into groups to conduct facilitated "focus group" discussions to build consensus around priority short and long term activities and resources or policies which should be pursued.

Attendance is free; registration is appreciated at www.pcrm.org/worldcongress.

 

Speakers

Warren Casey, NICEATM
Elan Ohayon, Green Neuroscience Laboratory
Kathy Hessler, Lewis and Clark Law School
Ed LeCluyse, LifeNet Health
Joyce Tischler, ALDF
Rebecca Ram, Lush Prize
Anja Wilmes, Medical University of Innsbruck

Moderator: Ann Lam, PCRM

For more information please contact Ann Lam at alam@pcrm.org.


 

EU-ToxRisk: the Horizon2020 approach for non-animal consumer protection


Wednesday August 23, 2017, 12:15-13:00
Room 615-616

The vision of the EU-ToxRisk project is to drive the required paradigm shift in toxicological testing away from ‘black box’  animal testing towards a toxicological assessment based on human cell responses and a comprehensive mechanistic under- standing of cause-consequence relationships leading to chemical adverse effects. EU-ToxRisk will integrate advances in cell biology, -omics technologies, systems biology and computational modelling to define the complex chain of events that link chemical exposure to toxic outcome. The focus of this project is on two areas: repeated dose systemic toxicity, using the lung, kidney, liver and nervous system as examples of potential target organs; and developmental and reproductive toxicity . It will also provide guidance for its universal application, allowing pushing the entire field forward in an integrated manner towards a mechanism-based chemical safety testing strategy.
“EU-ToxRisk: the Horizon2020 approach for non-animal consumer protection”
 
12:15-12:30   Bob van de Water (Co-ordinator, Leiden University, The Netherlands)  "EU-ToxRisk and Complex Model Systems: an Update on Status Quo"
 
12:30-12:40   Thomas Hartung (Johns Hopkins University, CAAT, USA)  "Read-Across and Prediction of Biological Response" 
 
12:40-12:50   Paul Jennings (AIMMS, The Netherlands)   "EU-ToxRisk Mitotoxicity Case Study: Mode of Action Based Biological Read Across of Mitochondrial Toxicity"
 
12:50-13:00   Andrew White (Unilever PLC, UK) "The Industry Perspective on Implementation of Integrated NAM Approaches and Regulatory Acceptance"